Indigenous plants such as lemongrass and celery are rich sources of nutrients. There is a need to test their efficacy for ameliorating nephrotoxicity. Plant-derived drugs have emerged as alternative medicine. Previous studies have focused only on the formulation of detoxifying drinks but lack efficacy validation based on animal or human trials. The present research was conducted to formulate and evaluate the nutritional composition and antioxidant potential of detoxifying drink variants and to assess their ameliorative effect on the renal toxicity induced by carbon tetrachloride (CCl₄) at 0.5ml/kg/day i.p in Wistar albino rats. Different detoxifying drink variants were prepared by adding 0.5%, 1.0% and 1.5% of lemongrass powder (LG5, LG10 and LG15) and celery powder (CL5, CL10 and CL15) respectively to the standard drink (SD). These additions resulted in a significant increase (p≤0.05) in all the nutritional parameters. In vivo data revealed that CCl₄ induced toxicity by increasing malondialdehyde (MDA) (6.87nmoles/ ml RBC lysate), decreased glutathione (GSH) (3.44µmole/ml RBC lysate) concentration and attenuated antioxidant enzymes activity (U/mg protein) of SOD (0.82), GPx (5.83) and CAT (1.66). Detoxifying drinks significantly ((p≤0.05) corrected urea, uric acid and creatinine levels in plasma. The rat group receiving LG15 and CL15 variant of detoxifying drink restored the enzymatic (SOD, GPx and CAT) activity (p≤0.05), non-enzymatic parameters (GSH) and attenuated the lipid peroxidation in erythrocyte lysate. The detoxifying drink variant with 1.5% celery powder was equivalent to silymarin (herbal medicine) in protecting the kidney against CCL₄ induced toxicity.